Marjeta Urh, ... Kate Zhao, in Methods in Enzymology, 2009. 2.4 Magnetic affinity beads. Magnetic separation can significantly shorten the purification process by quick retrieval of affinity beads at each step (e.g., binding, wash, and elution), and reduce sample dilution usually associated with traditional column-based elution. The method can be used on viscous materials that will otherwise ... Magnetic separation Precipitation Lets discuss some of the separation techniques. ... Simple distillation is a method used for the separation of components of a mixture containing two miscible liquids that boil without decomposition and have sufficient difference in their boiling points.